1-3-Dimethylaminopropyl-3-ethylcarbodiimide,1892-57-5

Cat.No.:

IC-02351001

Product Information

Biological Activity

N-(3-dimethylaminopropyl)-N¡ä-ethylcarbonyldiamine and N-hydroxysuccinimide (NHS) are often used together to activate the carbonyl group in carbodiimide coupling reactions and to couple with the amine to form amides.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical structure

Chemical Information

Molecular Weight

155.24

Formula

C8H17N3

CAS Number

1892-57-5

Purity

>95.00%

Solubility

Soluble in water

Storage

-20¡ãC

Order Information

Cat./REF.

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

Stock

IC-02351001

1g

$358.80

430.56 €

£¤3,588.00

 £¤71,401.20

In Stock

IC-02351001

5g

$565.00

678.00 €

£¤5,650.00

 £¤112,435.00

In Stock

IC-02351001

25g

$865.00

1,038.00 €

£¤8,650.00

 £¤172,135.00

In Stock

Free Delivery on orders over $350.00.

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