Flubendazole,31430-15-6

Cat.No.:IC-01210499

Product Information

Biological Activity

Flubendazole is an antiperspirant based on altering microtubule structure, inhibiting tubulin polymerization and disrupting microtubule function. Flubendodium induces apoptosis in human colorectal cancer (CRC) cells by blocking the STAT3 signaling axis and autophagy activation. Flubendazole induces P53 expression and reduces Cyclin B1 and p-cdc2 expression. Flubendazole is an anti-tumor agent. Flubendazole can be used to remove worms and intestinal parasites.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical structure

Chemical Information

M.Weight

313.28

Formula

C16H12FN3O3

CAS No.

31430-15-6

Purity

 >98.00%

Solubility

4.17 mg/mL  in DMSO

Storage

Sealed in dry,RoomTemperature

Reference

1. Shichong Lin, et al. Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy. J Exp Clin Cancer Res. 2019 Jul 8;38(1):293.  [Content Brief]
2. Zhou X, et al. Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis. Cell Death Discov. 2018 Feb 14;4:18.  [Content Brief]

Order Information

Cat./REF.

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

IC-01210499

1ml(10mM)

$89.10

€ 106.92

£¤891.00

£¤17,730.90

IC-01210499

100mg

$81.00

€ 97.20

£¤810.00

£¤16,119.00

IC-01210499

500mg

$121.50

€ 145.80

£¤1,215.00

£¤24,178.50

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