Curcumin,458-37-7

Cat.No.:IC-01257416

Product Information

Biological Activity

Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-¦ÊB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical structure

Chemical Information

M.Weight

368.38

Formula

C21H20O6

CAS No.

458-37-7

Purity

98.00%

Solubility

DMSO:100 mg/mL (271.46 mM)

Storage

-20¡æ

Reference

[1]Cao A, Li Q, et al. Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress. Apoptosis. 2013 Nov;18(11):1391-402.
[2]Gao S, Duan X, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Sep;59:739-47.
[3]Tsuda T . Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives. Food Funct. 2018 Feb 21;9(2):705-714. doi: 10.1039/c7fo01242j. PMID: 29206254.
[4]Daverey A, Agrawal SK. Curcumin Protects against White Matter Injury through NF-¦ÊB and Nrf2 Cross Talk. J Neurotrauma. 2020 May 15;37(10):1255-1265. doi: 10.1089/neu.2019.6749. Epub 2020 Feb 5. PMID: 31914858.

Order Information

Cat./REF.

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

Stock

IC-01257416

100mg

$60.00

72.00 €

£¤600.00

 £¤11,940.00

In Stock

IC-01257416

500mg

$88.00

105.60 €

£¤880.00

 £¤17,512.00

In Stock

IC-01257416

1g

$175.00

210.00 €

£¤1,750.00

 £¤34,825.00

In Stock

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