Enalapril,75847-73-3

Cat.No.:IC-01236658  

Product Information

Biological Activity

Enalapril (MK-421) is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research[1][2].

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical structure

Chemical Information

M.Weight

376.45

Formula

C20H28N2O5

CAS No.

75847-73-3

Purity

¡Ý98%

Solubility

DMSO:100 mg/mL (265.64 mM),H2O:50 mg/mL (132.82 mM)

Storage

2-8¡æ, protect from light

Reference

[1]. Serge Sicouri, et al. Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations. J Cardiovasc Electrophysiol. 2011 Jun;22(6):698-705.
[2]. Rokhsareh Meamar, et al. Enalapril protects endothelial cells against induced apoptosis in Alzheimer''''s disease. J Res Med Sci. 2013 Mar;18(Suppl 1):S1-5.
[3]. Talita A Cunha, et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS PharmSciTech. 2013 Sep;14(3):1150-7.
[4]. A Ravati, et al. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. Eur J Pharmacol. 1999 May 28;373(1):21-33.

Order Information

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

100mg

$32.00

€ 35.00

£¤320.00

£¤9,950.00

500mg

$80.00

€ 96.00

£¤800.00

£¤15,920.00

5g

$260.00

€ 312.00

£¤2,600.00

£¤51,740.00

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